HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 6-Methylpyrazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 6-Methyl-pyrazine-2-carboxylic acid {3-[3-(2-oxo-propoxy)-benzoyl-amino]-adamantan-1-yl}-amide | HCID 59161094 | — |
| Reactant | HCID 178418689 | HCID 178418689 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 6-Methylpyrazine-2-carboxylic acid | HCID 470897 | — |
| Product | 6-Methyl-pyrazine-2-carboxylic acid {3-[3-(2-hydroxy-2-methylpropoxy)-benzoylamino]-adamantan-1-yl}-amide | HCID 59161066 | — |
Reaction Steps
Reaction of 6-methyl-pyrazine-2-carboxylic acid {3-[3-(2-oxo-propoxy)-benzoyl-amino]-adamantan-1-yl}-amide with MeMgBr in THF or ether at 0° C. could yield the title compound, 6-methyl-pyrazine-2-carboxylic acid {3-[3-(2-hydroxy-2-methylpropoxy)-benzoylamino]-adamantan-1-yl}-amide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389519B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-2b3b634373dc41208eac09e2f9ddb1b7 |
| Source note | uspto-grants-2013_03 |