Diethyl Ether → Erlotinib Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Erlotinib free base (5 gm, obtained in step-II) is dissolved in chloroform (200 ml) at 25-30° C. to form a clear solution and then is added diethyl ether (50 ml). To the resulting solution is slowly added 15% diethyl ether HCl (5 ml) at 25-30° C. and stirred for 30 minutes at 25-30° C. The material, is filtered washed with a mixture of diethyl ether (10 ml) and chloroform (10 ml), and then dried at 60-65° C. under vacuum to give 4.9 gm of erlotinib hydrochloride [HPLC purity: 99.7%; Content of N-methoxyethyl impurity: 0.24% (at 1.14 RRT)].

Provenance & Evidence