Water → 1-(3-Fluoropyridin-2-yl)piperidin-4-one

HRID 1942265Notes

Reaction equation

HRID 1942265 reaction equation
[F:1][C:2]1[C:3]([N:8]2[CH2:17][CH2:16][C:11]3(COOC3)[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[OH2:18]>C(O)(=O)C>[F:1][C:2]1[C:3]([N:8]2[CH2:17][CH2:16][C:11](=[O:18])[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 962WaterHCID 86641932HCID 86641932, compound

Product 1

HCID 592163661-(3-Fluoropyridin-2-yl)piperidin-4-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

8-(3-fluoro-pyridin-2-yl)-2,3-dioxa-8-azaspiro[4.5]decane 17 (347 g, 1.456 Mol) was dissolved in acetic acid (700 mL) and water (140 mL) and the mixture heated to 85° C. under nitrogen for 18 h. LC/MS shows the reaction at 92% conversion at this stage. The mixture was evaporated to dryness in vacuo, to leave orange oil. This material was used directly in the next step without further purification

Workup

  1. customthe reaction at 92% conversion at this stage
  2. customThe mixture was evaporated to dryness in vacuo
  3. customto leave orange oil
  4. customThis material was used directly in the next step without further purification

Sources & evidence

ORD record
ord-81c0f26e3e61450391cbf1f68bd039c7
Source dataset
uspto-grants-2013_03
Patent number
US08389549B2

Reaction notes

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