Water ethanol → HCID 68412965, compound

Participants

Reaction Steps

3′-Fluoro-3,6-dihydro-2H-[1,2′]bipyridinyl-4-carbonitrile 20 (10.0 g, 49.2 mMol) was dissolved in ethanol:water (2:1, 150 mL) with stirring and heating. PtH(PMe2O)2(PMe2OH) (50 mg, 0.025 mol %) was added and the solution stirred under reflux for 2 h. LC/MS showed the reaction to be 100% complete after this time. The cooled solution was evaporated to dryness in vacuo to leave a white solid. The solid was filtered through a flash pad of silica gel to remove the catalyst to give the title compound as a white solid (10.9 g, 100%).

Provenance & Evidence