4-Aminotetrahydropyran → HCID 46872518, compound

Participants

Reaction Steps

As described in example 2, 6-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester (200 mg, 0.62 mmol) instead of 6-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester, and 4-aminotetrahydropyran instead of isopropylamine, was converted to the title compound (188 mg, 77%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol 100:0 to 95:5). MS: m/e=390.4 [M+H]+.

Provenance & Evidence