2-Aminopropanol → HCID 59455877, compound

Participants

Reaction Steps

As described in example 4, 6-[(E)-2-(5-methyl-3-phenyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester (200 mg, 0.62 mmol), using DL-2-amino-1-propanol instead of ethanolamine, was converted to the title compound (170 mg, 75%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol 100:0 to 93:7). MS: m/e=364.4 [M+H]+.

Provenance & Evidence