反应详情

To a stirred solution of PCC (4.96 g, 23 mmol) and anhydrous magnesium sulfate (7.40 g, 61 mmol) in DCM (60 mL) was added a solution of (3-butyl-5-methyl-isoxazol-4-yl)-methanol (2.6 g, 15 mmol) in DCM (60 mL) at room temperature and under argon. After 3 h the reaction mixture was diluted with ether (100 mL) and filtered through a bed of silica and the filtrate was concentrated. Purification by chromatography (silica heptane:ethyl acetate=100:0 to 1:1) afforded the title compound (2.15 g, 84%) as a colorless liquid. MS: m/e=170.3 [M+H]+.

1. filtrationfiltered through a bed of silica
2. concentrationthe filtrate was concentrated
3. customPurification by chromatography (silica heptane:ethyl acetate=100:0 to 1:1)