2-Aminopropanol → HCID 46872520, compound

Participants

Reaction Steps

As described in example 4, 6-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester (100 mg, 0.28 mmol) instead of 6-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-nicotinic acid methyl ester, and DL-2-amino-1-propanol instead of ethanolamine, was converted to the title compound (85 mg, 87%) which was obtained as a light yellow oil after purification by chromatography (silica, dichloromethane:methanol 100:0 to 94:6). MS: m/e=364.4 [M+H]+.

Provenance & Evidence