4-Aminotetrahydropyran → HCID 46872639, compound

Participants

Reaction Steps

As described in example 9, 6-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-nicotinic acid methyl ester (100 mg, 0.28 mmol), and 4-aminotetrahydropyran instead of tetrahydrofuran-3-amine, was converted to the title compound (56 mg, 46%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol 100:0 to 96.5:3.5) and trituration with isopropyl ether. MS: m/e=328.4 [M+H]+.

Provenance & Evidence