HCID 46872520, compound → HCID 59455878, compound

Participants

Reaction Steps

A stirred mixture of 6-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-N-(2-hydroxy-1-methyl-ethyl)-nicotinamide (example 10, 32 mg, 0.093 mmol) and 10% Palladium on charcoal (5 mg) in ethanol (5 mL) was shaken under an atmosphere of hydrogen for 2 h. The reaction mixture was filtered and concentrated. Purification by chromatography (silica, dichloromethane:methanol 100:0 to 9:1) afforded the title compound (20 mg, 63%) as a colorless oil. MS: m/e=364.4 [M+H]+.

Provenance & Evidence