HCID 46872521, compound → HCID 46872633, compound

Participants

Reaction Steps

A stirred mixture of 6-[(E)-2-(3-butyl-5-methyl-isoxazol-4-yl)-vinyl]-N-(tetrahydro-furan-3-yl)-nicotinamide (31 mg, 0.087 mmol) and 10% Palladium on charcoal (5 mg) in ethanol (5 mL) was shaken under an atmosphere of hydrogen for 3 h. The reaction mixture was filtered and concentrated. Purification by chromatography (silica, dichloromethane:methanol 100:0 to 9:1) afforded the title compound (17 mg, 55%) as a colorless oil. MS: m/e=328.4 [M+H]+.

Provenance & Evidence