Hydrochloric Acid → HCID 59201245, compound

Participants

Reaction Steps

A solution of LiOH (5 mg, 0.209 mmol) in H2O (0.5 ml) was added to a stirred solution of the ester (Step 1, 13 mg, 0.028 mmol) in THF (1 ml) at RT. The mixture was stirred at RT for 3 days. 2N HCl (0.5 ml) was added. The pH of the aqueous layer was adjusted to ˜7 with NaHCO3 (aq). The aqueous layer was extracted with DCM (×3). The combined extracts were dried (Na2SO4), filtered and evaporated to give the title compound (12 mg) as a colourless solid after evaporation from pentane. M/Z 452 (MH+).

Provenance & Evidence