Hydrochloric Acid → HCID 59201220, compound

Participants

Reaction Steps

A solution of lithium hydroxide (41 mg, 1.702 mmol) in water (1 ml) was added to a stirred solution of methyl {(2S,4R)-1-[(1R,4R/S)-5-(benzyloxy)-4-methyl-1-(3,3,3-trifluoropropyl)pentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (Step 1, 200 mg, 0.340 mmol) in THF (2 ml) at RT. The mixture was stirred at RT o/n. 2N HCl (1 ml) was added The pH of the aqueous layer was adjusted to 7 with NaHCO3 (aq). The aqueous layer was extracted with DCM (×3). The combined extracts were dried (Na2SO4), filtered and evaporated. The residue was purified by chromatography (silica, 2-4% MeOH/DCM) to give the title compound (180 mg) as a colourless foam/M/Z 574 (MH+).

Provenance & Evidence