反应详情

温度

150 °C

A mixture of (±)-methyl{(2S,4R)-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (Intermediate 1, 453 mg, 1.5 mmol), 4-methylpentanal (150 mg, 1.5 mmol) and benzotriazole (178.5 mg, 1.5 mmol) were combined in toluene (15 ml) and the reaction was stirred and heated a 150° C. under Dean-Stark conditions for 16 Hrs. The mixture was evaporated in vacuo to provide a pale gum.

1. customThe mixture was evaporated in vacuo
2. customto provide a pale gum