Potassium hydroxy sulfite → 5-Iodo-2-(methanesulfinyl)imidazo[2,1-b][1,3,4]thiadiazole

HRID 1942319Notes

Reaction equation

HRID 1942319 reaction equation
[OH:1]OS([O-])=O.[K+].[I:7][C:8]1[N:15]2[C:11]([S:12][C:13]([S:16][CH3:17])=[N:14]2)=[N:10][CH:9]=1>CO.O>[I:7][C:8]1[N:15]2[C:11]([S:12][C:13]([S:16]([CH3:17])=[O:1])=[N:14]2)=[N:10][CH:9]=1

Participants

5

Reactant 2

HCID 23707502Potassium hydroxy sulfiteHCID 667497445-Iodo-2-(methylsulfanyl)imidazo[2,1-b][1,3,4]thiadiazole

Product 1

HCID 671090085-Iodo-2-(methanesulfinyl)imidazo[2,1-b][1,3,4]thiadiazole

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

Oxone(r), monopersulfate compound (263.99 mg; 0.43 mmol; 1.00 eq.) was added to a solution of 5-iodo-2-methylsulfanyl-imidazo[2,1-b][1,3,4]thiadiazole (127.60 mg; 0.43 mmol; 1.00 eq.) in MeOH (1.50 ml) and water (1.50 ml) at room temperature. After 1 h, the reaction was finished. Water was added and the reaction was extracted 2 times with dichloromethane. The combined organic extracts were dried over magnesium sulphate, filtered and concentrated to give 106.9 mg of the desired product as a beige solid.

Workup

  1. extractionthe reaction was extracted 2 times with dichloromethane
  2. dry with materialThe combined organic extracts were dried over magnesium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-7bf35e1aa53d4e0a835006d2b6360c00
Source dataset
uspto-grants-2013_03
Patent number
US08389554B2

Reaction notes

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