2-(4-Chlorophenyl)thiazole-5-carboxylic acid → HCID 66937657, compound

HRID 1942349Notes

Reaction equation

HRID 1942349 reaction equation
ClC1C=C(Cl)C=CC=1C=CC([N-:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])=O.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[S:27][C:28]([C:31]([OH:33])=O)=[CH:29][N:30]=2)=[CH:22][CH:21]=1>>[OH:13][CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:31]([C:28]1[S:27][C:26]([C:23]2[CH:22]=[CH:21][C:20]([Cl:19])=[CH:25][CH:24]=2)=[N:30][CH:29]=1)=[O:33]

Participants

3

Reactant 2

HCID 108000442-(4-Chlorophenyl)thiazole-5-carboxylic acidHCID 178520459HCID 178520459, compound

Product 1

HCID 66937657HCID 66937657, compoundYield 95%

Procedure

2-(4-Chloro-phenyl)-thiazole-5-carboxylic acid (4-hydroxy-butyl)-amide (19A) is prepared as described for 17A starting with 2-(4-Chloro-phenyl)-thiazole-5-carboxylic acid.

Sources & evidence

ORD record
ord-1a729e91769141ed85a6e5580eff12fe
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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