HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942351Generated: November 4, 2026
Thionyl Chloride → 1,2,3,4-Tetrahydronaphthalene-2-carbonyl chloride
https://huagongshe.com/reaction/1942351
Participants
| Role | Name | HCID | Charge |
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| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1,2,3,4-Tetrahydro-2-naphthoic acid | HCID 101370 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1,2,3,4-Tetrahydronaphthalene-2-carbonyl chloride | HCID 15670790 | — |
Reaction Steps
6.5 mmol (1.15 g) 1,2,3,4-Tetrahydro-naphthalene-2-carboxylic acid is dissolved in 20 mL toluene, 20 mL of thionylchloride are added, the mixture is heated to 60° C. in an oil bath for 2 hours. Then the mixture is concentrated in vacuum. Toluene is added to the residue and evaporated again. The crude product is obtained in almost quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08389555B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-1a5a32472c094ced928c1d5034a3a950 |
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| Source note | uspto-grants-2013_03 |
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