3,4-Dihydroisoquinoline-2(1H)-carbonyl chloride → 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (4,4-diethoxy-butyl)-amide

HRID 1942354Notes

Reaction equation

HRID 1942354 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11](Cl)=[O:12].[CH2:14]([O:16][CH:17]([O:30][CH2:31][CH3:32])[CH2:18][CH2:19][CH2:20][NH:21]C(C1CCCCC1)=O)[CH3:15]>>[CH2:31]([O:30][CH:17]([O:16][CH2:14][CH3:15])[CH2:18][CH2:19][CH2:20][NH:21][C:11]([N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1)=[O:12])[CH3:32]

Participants

3

Reactant 2

HCID 218905713,4-Dihydroisoquinoline-2(1H)-carbonyl chlorideHCID 66937511HCID 66937511, compound

Product 1

HCID 669374713,4-Dihydro-1H-isoquinoline-2-carboxylic acid (4,4-diethoxy-butyl)-amide

Procedure

3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (4,4-diethoxy-butyl)-amide (24B) is prepared from 24A as described for 20A.

Sources & evidence

ORD record
ord-57cdc74ddf9d439ca7ecedb2eab50fb1
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

Loading…