6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline → 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl chloride

HRID 1942356Notes

Reaction equation

HRID 1942356 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][NH:8][CH2:7][CH2:6]2.C1C2C(=CC=CC=2)CCN1[C:25]([Cl:27])=[O:26]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][N:8]([C:25]([Cl:27])=[O:26])[CH2:7][CH2:6]2

Participants

3

Reactant 2

HCID 156236,7-Dimethoxy-1,2,3,4-TetrahydroisoquinolineHCID 218905713,4-Dihydroisoquinoline-2(1H)-carbonyl chloride

Product 1

HCID 798861106,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl chlorideYield 94%

Procedure

6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride (25A) is prepared from 6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline as described for 24A.

Sources & evidence

ORD record
ord-a26ccbe43afd4f5c920f21fc0c134631
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

Loading…