N-(4-oxo-butyl)-benzamide → 6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-oxo-butyl)-amide

HRID 1942358Notes

Reaction equation

HRID 1942358 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[CH2:10]1)=[O:8].O=CCCCNC(=O)C1C=CC=CC=1>>[O:1]=[CH:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[CH2:10]1)=[O:8]

Participants

3

Reactant 2

HCID 10352536N-(4-oxo-butyl)-benzamideHCID 669375406,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-hydroxy-butyl)-amide

Product 1

HCID 866513046,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-oxo-butyl)-amide

Procedure

6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-oxo-butyl)-amide (25C) is prepared from 25B as described for 1E. The crude product is obtained in almost quantitative yield.

Sources & evidence

ORD record
ord-bac66e0889354bad888636c8e1eb8167
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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