Benzamide, N-(4-hydroxybutyl)- → Indane-2-carboxylic acid-(4-hydroxybutyl)amide

HRID 1942360Notes

Reaction equation

HRID 1942360 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[C:10](Cl)=[O:11].[OH:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18]C(=O)C1C=CC=CC=1>>[OH:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:10]([CH:2]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1]1)=[O:11]

Participants

3

Reactant 2

HCID 11217773Benzamide, N-(4-hydroxybutyl)-HCID 213133822,3-dihydro-1H-indene-2-carbonyl chloride

Product 1

HCID 66937618Indane-2-carboxylic acid-(4-hydroxybutyl)amideYield 62%

Procedure

Indane-2-carboxylic acid-(4-hydroxybutyl)amide (26B) is prepared from 26A as described for 1D.

Sources & evidence

ORD record
ord-f740e803a0074b52940ec335dcd79cee
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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