Isoindoline → 1,3-Dihydro-2H-isoindole-2-carbonyl chloride

HRID 1942362Notes

Reaction equation

HRID 1942362 reaction equation
C1C2C(=CC=CC=2)CN1.[CH2:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]C[N:11]1[C:20]([Cl:22])=[O:21]>>[CH2:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][N:11]1[C:20]([Cl:22])=[O:21]

Participants

3

Reactant 2

HCID 422478IsoindolineHCID 218905713,4-Dihydroisoquinoline-2(1H)-carbonyl chloride

Product 1

HCID 450815381,3-Dihydro-2H-isoindole-2-carbonyl chlorideYield 77%

Procedure

1,3-Dihydro-isoindole-2-carbonyl chloride (27A) is prepared from 2,3-dihydro-1H-isoindole as described for 24A.

Sources & evidence

ORD record
ord-4b86dd5a01ff40099c46766f1c9c1c1a
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

Loading…