Benzamide, N-(4-hydroxybutyl)- → 1,3-Dihydro-isoindole-2-carboxylic acid-(4-hydroxybutyl)amide

HRID 1942363Notes

Reaction equation

HRID 1942363 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[C:10](Cl)=[O:11].[OH:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18]C(=O)C1C=CC=CC=1>>[OH:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:10]([N:2]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1]1)=[O:11]

Participants

3

Reactant 2

HCID 11217773Benzamide, N-(4-hydroxybutyl)-HCID 450815381,3-Dihydro-2H-isoindole-2-carbonyl chloride

Product 1

HCID 669375761,3-Dihydro-isoindole-2-carboxylic acid-(4-hydroxybutyl)amideYield 97%

Procedure

1,3-Dihydro-isoindole-2-carboxylic acid-(4-hydroxybutyl)amide (27B) is prepared from 27A as described for 1D.

Sources & evidence

ORD record
ord-356d3a1281724ae0abd9506e3b0d3a83
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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