N-(4-oxo-butyl)-benzamide → 1,3-Dihydro-isoindole-2-carboxylic acid (4-oxo-butyl)-amide

HRID 1942364Notes

Reaction equation

HRID 1942364 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)=[O:8].O=CCCCNC(=O)C1C=CC=CC=1>>[O:1]=[CH:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)=[O:8]

Participants

3

Reactant 2

HCID 10352536N-(4-oxo-butyl)-benzamideHCID 669375761,3-Dihydro-isoindole-2-carboxylic acid-(4-hydroxybutyl)amide

Product 1

HCID 866513061,3-Dihydro-isoindole-2-carboxylic acid (4-oxo-butyl)-amide

Procedure

1,3-Dihydro-isoindole-2-carboxylic acid (4-oxo-butyl)-amide (27C) is prepared from 27B as described for 1E. The crude product is obtained in almost quantitative yield.

Sources & evidence

ORD record
ord-6f0c773f18044ac8a4e31ecdb91d83f2
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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