1,4-Dioxane → 2-isocyanato-2,3-dihydro-1H-indene

HRID 1942368Notes

Reaction equation

[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[NH2:10].[O:11]1CCOC[CH2:12]1>>[N:10]([CH:2]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1]1)=[C:12]=[O:11]

Participants

Reactant 2

HCID 312751,4-Dioxane

HCID 763102-Aminoindane

Product 1

HCID 578841982-isocyanato-2,3-dihydro-1H-indene

Procedure

A solution of 1.53 g (11.5 mmol) indan-2-ylamine and 1.39 mL (11.5 mmol) in 40 mL dry dioxane is stirred for 2 hours at 70° C. under argon atmosphere and then concentrated under vacuum.

Workup

concentrationconcentrated under vacuum

Sources & evidence

ORD record: ord-319b50276d24496b94f078b729ccef43
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389555B2

Reaction notes

Loading…