4-Phenyl-piperazine-1-carbonyl chloride → 4-Phenylpiperazine-1-carboxylic acid (4,4-diethoxybutyl)amide

HRID 1942372Notes

Reaction equation

HRID 1942372 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([O:18][CH:19]([O:32][CH2:33][CH3:34])[CH2:20][CH2:21][CH2:22][NH:23]C(C1CCCCC1)=O)[CH3:17]>>[CH2:33]([O:32][CH:19]([O:18][CH2:16][CH3:17])[CH2:20][CH2:21][CH2:22][NH:23][C:13]([N:10]1[CH2:11][CH2:12][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1)=[O:14])[CH3:34]

Participants

3

Reactant 2

HCID 153385594-Phenyl-piperazine-1-carbonyl chlorideHCID 66937511Cyclohexanecarboxylic acid (4,4-diethoxy-butyl)-amide

Product 1

HCID 669375364-Phenylpiperazine-1-carboxylic acid (4,4-diethoxybutyl)amide

Procedure

4-Phenylpiperazine-1-carboxylic acid (4,4-diethoxybutyl)amide (61B) is prepared from 61A as described for 20A. The product is obtained in almost quantitative yield.

Workup

  1. customThe product is obtained in almost quantitative yield

Sources & evidence

ORD record
ord-e9a863f2561348bdbd3a2416e5f99964
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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