Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amine → 4-Phenylpiperazine-1-carboxylic acid {4-[propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]butyl}amide
Reaction equation
[CH2:1]([NH:4][CH:5]1[CH2:13][CH2:12][C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6]1)[CH2:2][CH3:3].O=[CH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:24][CH2:23]1)=[O:21]>>[CH2:1]([N:4]([CH:5]1[CH2:13][CH2:12][C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6]1)[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:24][CH2:23]1)=[O:21])[CH2:2][CH3:3]Participants
3
Procedure
Compound 61 is prepared from 1C and 61C as described for 1. The salt of maleic acid is crystallized from acetonitrile/diethylether.
Workup
- customThe salt of maleic acid is crystallized from acetonitrile/diethylether
Sources & evidence
- ORD record
- ord-a3321e49831d414c871e3e098ec0ca2a
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08389555B2
Reaction notes
Loading…