Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amine → 4-Phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid {4-[propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]butyl}amide
Reaction equation
O=[CH:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:14][CH:13]=[C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=[O:8].[CH2:21]([NH:24][CH:25]1[CH2:33][CH2:32][C:28]2[N:29]=[CH:30][S:31][C:27]=2[CH2:26]1)[CH2:22][CH3:23]>>[CH2:21]([N:24]([CH:25]1[CH2:33][CH2:32][C:28]2[N:29]=[CH:30][S:31][C:27]=2[CH2:26]1)[CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:14][CH:13]=[C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=[O:8])[CH2:22][CH3:23]Participants
3
Reactant 2
Product 1
Procedure
Compound 62 is prepared from 62C and 1C as described for 1. The salt of maleic acid is crystallized from acetonitrile/diethylether.
Workup
- customThe salt of maleic acid is crystallized from acetonitrile/diethylether
Sources & evidence
- ORD record
- ord-b98a55d908db4647b77fe0c26a18926a
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08389555B2
Reaction notes
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