HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1,4-Dioxaspiro[4.5]decan-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,4-Dioxaspiro[4.5]decan-8-amine | HCID 14634315 | — |
Reaction Steps
To a solution of 9.36 g (60 mmol) 1,4-cyclohexanedione monoethylene acetal in 60 mL of methanol which has been saturated with ammonia, 0.6 g of palladium on carbon (10%) is added. The mixture is stirred overnight under 4 bar hydrogen pressure. Filtration over Celite and concentration in vacuum provides the crude product in almost quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389555B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-87011bd0f9274964aadf68a2b588dff8 |
| Source note | uspto-grants-2013_03 |