2-Aminoindan hydrochloride → N-Indan-2-yl-4-{[propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]methyl}benzamide
Reaction equation
[CH2:1]([N:4]([CH2:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1)[CH:5]1[CH2:13][CH2:12][C:8]2[N:9]=[CH:10][S:11][C:7]=2[CH2:6]1)[CH2:2][CH3:3].Cl.[CH2:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH:26]1[NH2:34].OCCCCNC(=O)C1C=CC=CC=1>>[CH2:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH:26]1[NH:34][C:19](=[O:20])[C:18]1[CH:22]=[CH:23][C:15]([CH2:14][N:4]([CH2:1][CH2:2][CH3:3])[CH:5]2[CH2:13][CH2:12][C:8]3[N:9]=[CH:10][S:11][C:7]=3[CH2:6]2)=[CH:16][CH:17]=1Participants
4
Procedure
Compound 44 is prepared from 42C and indan-2-ylamine hydrochloride as described for 1D.
Sources & evidence
- ORD record
- ord-c297b9d5b6fc41aca477ea136574379c
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08389555B2
Reaction notes
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