1,2,3,4-Tetrahydroisoquinoline → 2-(3,4-Dihydroisoquinolin-2(1H)-yl)ethanol

HRID 1942428Notes

Reaction equation

HRID 1942428 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.C[O:12][C:13]1C=CC=C[C:14]=1N1CCN(CCO)CC1>>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:14][CH2:13][OH:12]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 111073541-Piperazineethanol, 4-(2-methoxyphenyl)-

Product 1

HCID 2462882-(3,4-Dihydroisoquinolin-2(1H)-yl)ethanolYield 60%

Procedure

2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethanol (31A) is prepared from 1,2,3,4-tetrahydro-isoquinoline as described for 28A.

Sources & evidence

ORD record
ord-b59b34ec7b47479891af171141efbd2f
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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