3-(4-(2-Methoxyphenyl)piperazin-1-yl)propan-1-ol → 3-[4-(2,3-Dichlorophenyl)piperazin-1-yl]propan-1-ol

HRID 1942432Notes

Reaction equation

HRID 1942432 reaction equation
Cl.[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C[O:17][C:18]1C=CC=[CH:20][C:19]=1N1CCN(CCCO)CC1>>[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:20][CH2:19][CH2:18][OH:17])[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 4109013-(4-(2-Methoxyphenyl)piperazin-1-yl)propan-1-olHCID 116303721-(2,3-Dichlorophenyl)piperazine hydrochloride

Product 1

HCID 210732893-[4-(2,3-Dichlorophenyl)piperazin-1-yl]propan-1-olYield 82%

Procedure

3-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]propan-1-ol (36A) is prepared from 1-(2,3-dichloro-phenyl)-piperazine hydrochloride as described for 29A.

Sources & evidence

ORD record
ord-315cca250e38409f8a2615fb75a7ed1a
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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