1-Piperazineethanol, 4-(2-methoxyphenyl)- → 2-(4-Naphthoyl-piperazin-1-yl)-ethanol

HRID 1942438Notes

Reaction equation

HRID 1942438 reaction equation
Cl.[C:2]1([C:12]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.C[O:21][C:22]1C=CC=C[C:23]=1N1CCN(CCO)CC1>>[C:2]1([C:12]([N:14]2[CH2:19][CH2:18][N:17]([CH2:23][CH2:22][OH:21])[CH2:16][CH2:15]2)=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 111073541-Piperazineethanol, 4-(2-methoxyphenyl)-HCID 438105011-(Naphthalene-1-carbonyl)piperazine hydrochloride

Product 1

HCID 433908862-(4-Naphthoyl-piperazin-1-yl)-ethanolYield 30%

Procedure

2-(4-Naphthoyl-piperazin-1-yl)-ethanol (39B) is prepared from 39A as described for 28A.

Sources & evidence

ORD record
ord-4519f188763f4f5a8b19dafb5444a06f
Source dataset
uspto-grants-2013_03
Patent number
US08389555B2

Reaction notes

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