Sodium Hydroxide → HCID 58376294, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (2R,5R)-5-[[(benzyloxy)carbonyl](isopropyl)amino]-2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate (8.5 g) in ethanol (100 mL) was added a 2N aqueous sodium hydroxide solution (50 mL), and the mixture was stirred at 50° C. for one hour. The reaction solution was cooled with ice, and thereto was added an aqueous potassium hydrogen sulfate solution in order to adjust the pH value to pH 3. The mixture was extracted with chloroform, and the organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (6.0 g) as a colorless solid.

Provenance & Evidence