(S)-Atrolactic acid → HCID 67330699, compound

HRID 1942499Notes

Reaction equation

HRID 1942499 reaction equation
[OH:1][C@:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[C:3]([OH:5])=O.F[C:14]1[C:23]([N+:24]([O-])=O)=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[C:16]([C:27]([F:30])([F:29])[F:28])[CH:15]=1>>[CH3:6][C@:2]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3](=[O:5])[NH:24][C:23]2[CH:22]=[C:17]([C:18]([O:20][CH3:21])=[O:19])[C:16]([C:27]([F:30])([F:28])[F:29])=[CH:15][C:14]=2[O:1]1

Participants

3

Reactant 2

HCID 445144(S)-Atrolactic acidHCID 58376062HCID 58376062, compound

Product 1

HCID 67330699HCID 67330699, compound

Procedure

Using (2S)-2-hydroxy-2-phenylpropanoic acid and methyl 4-fluoro-5-nitro-2-(trifluoromethyl)-benzoate, the title compound was obtained in a similar manner to Reference Example 22 and Reference Example 2.

Sources & evidence

ORD record
ord-adeb17e71bac46b6b90e44cbbd85b57f
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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