(S)-Atrolactic acid → HCID 67331854, compound

HRID 1942505Notes

Reaction equation

HRID 1942505 reaction equation
F[C:2]1[CH:26]=[CH:25][C:5]([C:6]([N:8]([CH:22]([CH3:24])[CH3:23])[C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]2)=[O:7])=[CH:4][C:3]=1[N+:27]([O-])=O.[OH:30][C@:31]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)([CH3:35])[C:32](O)=[O:33]>>[CH:22]([N:8]([C:6]([C:5]1[CH:25]=[CH:26][C:2]2[O:30][C@@:31]([CH3:35])([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:32](=[O:33])[NH:27][C:3]=2[CH:4]=1)=[O:7])[C@@H:9]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]1)([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 445144(S)-Atrolactic acidHCID 58375846HCID 58375846, compound

Product 1

HCID 67331854HCID 67331854, compound

Procedure

Using tert-butyl (3R)-3-[(4-fluoro-3-nitrobenzoyl)(isopropyl)amino]piperidine-1-carboxylate and (2S)-2-hydroxy-2-phenylpropanoic acid, the title compound was obtained in a similar manner to Reference Example 22 and Reference Example 2.

Sources & evidence

ORD record
ord-6c0aef70ae754ce9a34779634509f8ad
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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