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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942521Generated: October 28, 2026

1-Piperidinecarboxylic acid, 3-amino-4-phenyl-, 1,1-dimethylethyl ester, (3R,4R)-rel- → HCID 67330662, compound

https://huagongshe.com/reaction/1942521

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Piperidinecarboxylic acid, 3-amino-4-phenyl-, 1,1-dimethylethyl ester, (3R,4R)-rel-HCID 25324006—
Reactant4-(4-Methoxybutyl)-2,2-dimethyl-3-oxo-7-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acidHCID 58375807—
ProductHCID 67330662HCID 67330662—

Reaction Steps

Using 4-(4-methoxybutyl)-2,2-dimethyl-3-oxo-7-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acid and tert-butyl (3S,4S)-3-amino-4-phenylpiperidine-1-carboxylate, the title compound was obtained in a similar manner to Reference Example 541.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389511B2
Source datasetuspto-grants-2013_03
ORD IDord-526e60522b214dd580946ec80e6df92d
Source noteuspto-grants-2013_03