HCID 58375885, compound → HCID 67330954, compound

HRID 1942523Notes

Reaction equation

HRID 1942523 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][N:14]1[C:19]2[CH:20]=[C:21]([C:28](OC)=[O:29])[C:22]([C:24]([F:27])([F:26])[F:25])=[CH:23][C:18]=2[O:17][C:16]([CH3:33])([CH3:32])[C:15]1=[O:34])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:35]([NH:37][C@@H:38]1[C@@H:43]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH2:42][CH2:41][N:40]([C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])[CH2:39]1)[CH3:36]>>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][N:14]1[C:19]2[CH:20]=[C:21]([C:28]([N:37]([CH2:35][CH3:36])[C@@H:38]3[C@@H:43]([C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)[CH2:42][CH2:41][N:40]([C:50]([O:52][C:53]([CH3:55])([CH3:54])[CH3:56])=[O:51])[CH2:39]3)=[O:29])[C:22]([C:24]([F:25])([F:26])[F:27])=[CH:23][C:18]=2[O:17][C:16]([CH3:32])([CH3:33])[C:15]1=[O:34])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 58375885HCID 58375885, compoundHCID 67333487HCID 67333487, compound

Product 1

HCID 67330954HCID 67330954, compound

Procedure

Using methyl 4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2-dimethyl-3-oxo-7-(trifluoro-methyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate and tert-butyl (3R,4R)-3-(ethylamino)-4-phenylpiperidine-1-carboxylate, the title compound (60.4 mg) was obtained in a similar manner to Reference Example 5.

Sources & evidence

ORD record
ord-1c658aa2571a4d8a902eeb247390e0e2
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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