HCID 58376142, compound → HCID 67331350, compound

HRID 1942528Notes

Reaction equation

HRID 1942528 reaction equation
[CH2:1]([N:8]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:9][CH2:10][N:11]1[C:16]2[CH:17]=[C:18]([C:22](O)=[O:23])[C:19]([F:21])=[CH:20][C:15]=2[O:14][C:13]([CH3:26])([CH3:25])[C:12]1=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:35][C@@H:36]1[C@@H:41]([C:42]2[CH:47]=[C:46]([F:48])[C:45]([F:49])=[CH:44][C:43]=2[F:50])[CH2:40][CH2:39][N:38]([C:51]([O:53][C:54]([CH3:57])([CH3:56])[CH3:55])=[O:52])[CH2:37]1>>[CH2:28]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][CH2:10][N:11]1[C:16]2[CH:17]=[C:18]([C:22]([NH:35][C@@H:36]3[C@@H:41]([C:42]4[CH:47]=[C:46]([F:48])[C:45]([F:49])=[CH:44][C:43]=4[F:50])[CH2:40][CH2:39][N:38]([C:51]([O:53][C:54]([CH3:57])([CH3:56])[CH3:55])=[O:52])[CH2:37]3)=[O:23])[C:19]([F:21])=[CH:20][C:15]=2[O:14][C:13]([CH3:26])([CH3:25])[C:12]1=[O:27])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 58376142HCID 58376142, compoundHCID 67331021HCID 67331021, compound

Product 1

HCID 67331350HCID 67331350, compound

Procedure

Using 4-[2-(dibenzylamino)ethyl]-7-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acid and tert-butyl (3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidine-1-carboxylate, the title compound was obtained in a similar manner to Reference Example 541.

Sources & evidence

ORD record
ord-6114e22797534f3a9f81461ce8f2f953
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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