反应详情

To a suspension of 4-fluoro-2-methylbenzoic acid (32.5 g) in conc. sulfuric acid (50 ml) was added dropwise conc. nitric acid (8.4 ml) at 0° C., and the mixture was stirred at room temperature for 5 hours. The reaction mixture was poured into ice-water (500 ml), and the mixture was extracted with diisopropyl ether (300 ml), and the organic layer was washed with water, and a saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered, concentrated under reduced pressure to give the title compound (40.0 g).

1. extractionthe mixture was extracted with diisopropyl ether (300 ml)
2. washthe organic layer was washed with water
3. dry with materiala saturated aqueous sodium chloride solution, dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure