Ammonium Chloride → HCID 86656372, compound

Participants

Reaction Steps

A solution of ethyl 6-{[[(3R)-1-(tert-butoxycarbonyl)piperidin-3-yl](isopropyl)amino]-carbonyl}-4-(4-methoxybutyl)-2-methyl-3-oxo-7-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate (150 mg) in tetrahydrofuran (2 ml) was cooled with ice, and thereto was added dropwise methylmagnesium bromide (1M tetrahydrofuran solution, 1.2 ml), and the mixture was stirred at room temperature for 3 hours. To the reaction solution was added a saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with a saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (111 mg).

Provenance & Evidence