HCID 57917772, compound → HCID 67333285, compound

HRID 1942552Notes

Reaction equation

HRID 1942552 reaction equation
[NH2:1][C:2]1[C:3]([OH:31])=[CH:4][C:5]([C:27]([F:30])([F:29])[F:28])=[C:6]([CH:26]=1)[C:7]([N:9]([CH:23]([CH3:25])[CH3:24])[C@@H:10]1[CH2:15][CH2:14][CH2:13][N:12]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:11]1)=[O:8].Br[CH:33]([CH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1)[C:34](Cl)=[O:35]>>[CH:23]([N:9]([C:7]([C:6]1[C:5]([C:27]([F:30])([F:28])[F:29])=[CH:4][C:3]2[O:31][CH:33]([CH:37]3[CH2:42][CH2:41][O:40][CH2:39][CH2:38]3)[C:34](=[O:35])[NH:1][C:2]=2[CH:26]=1)=[O:8])[C@@H:10]1[CH2:15][CH2:14][CH2:13][N:12]([C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:11]1)([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 57917772HCID 57917772, compoundHCID 58376512HCID 58376512, compound

Product 1

HCID 67333285HCID 67333285, compound

Procedure

Using tert-butyl (3R)-3-[[5-amino-4-hydroxy 2-(trifluoromethyl)benzoyl](isopropyl)amino]-piperidine-1-carboxylate and bromo (tetrahydro-2H-pyran-4-yl)acetyl chloride, the title compound was obtained in a similar manner to Reference Example 55.

Sources & evidence

ORD record
ord-d2f33428490c4314a3d34027edea6c5e
Source dataset
uspto-grants-2013_03
Patent number
US08389511B2

Reaction notes

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