Ethylamine → HCID 58376069, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl (3R)-3-[[4-chloro-5-nitro-2-(trifluoromethyl)benzoyl](isopropyl)-amino]piperidine-1-carboxylate (930 mg) in ethanol (6 ml) was added ethylamine (2M methanol solution, 10 ml), and the mixture was stirred at 80° C. for 2 hours. The mixture was cooled, and the reaction solution was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (610 mg).

Provenance & Evidence