Water → HCID 58494111, compound

Participants

Reaction Steps

To a solution of 2-(3-bromo-2-ethyl-phenyl)-malonic acid diethyl ester (D127) (13 g, 37.88 mmol) in methanol (130 mL) was added sodium borohydride (14.33 g, 378.78 mmol), the reaction mixture was stirred for 12 hr at room temperature. Then water was added and extracted with CH2Cl2. The organic layers were separated, dried over Na2SO4, and concentrated in vacuo to afford 2-(3-bromo-2-ethyl-phenyl)-propane-1,3-diol (D128) (8 g). MS (ES): C11H15BrO2 requires 258.0. found 223.0 (M+H+-36).

Provenance & Evidence