Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzhydrylamine | HCID 7036 | — |
| Reactant | Trifluoromethanesulfonic anhydride | HCID 67749 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 58494111 | HCID 58494111 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86659010 | HCID 86659010 | 24.5% |
Reaction Steps
A mixture of 2-(3-bromo-2-ethyl-phenyl)-propane-1,3-diol (D128) (8 g, 30.87 mmol) in 150 mL of CH3CN was added diphenylmethylamine (5.66 g, 30.87 mmol), trifluoromethanesulfonic anhydride, DIPEA at 0° C., and the reaction mixture was stirred for 12 hr at 70° C., then the reaction mixture was concentrated in vacuo. The residue was purified by column chromatography to afford 1-benzhydryl-3-(3-bromo-2-ethyl-1-methylene-but-2-enyl)-azetidine (D129) (3 g,).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08389508B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-1476b6867fc44f87b5a1a1c86dc06d53 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
