反应详情

1-{[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]methyl}-3-azetidinecarboxylic acid (50 mg, 0.106 mmol) was added to a mixture of THF (2 mL), water (0.6 mL) and ACN (1 mL), a suspension was obtained to which was added HBr solution (0.016 mL, 40%, wt). A clear solution was obtained and stirred for 30 min at rt. Solvent was removed under the reduced pressure and dried in vacuum to give 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium bromide (56 mg) as pale yellow solid. δH (DMSO-d6, 600 MHz): 1.08 (3H, t), 1.35 (6H, m), 2.92 (2H, m), 3.67 (1H, m), 4.34 (4H, m), 4.61 (2H, m), 4.85 (1H, dt), 7.39 (1H, d), 7.48 (1H, m), 7.64 (2H, m), 7.97 (1H, d), 8.10 (1H, d), 10.25 (1H, s), 13.17 (1H, d).

1. customa suspension was obtained to which
2. customA clear solution was obtained
3. customSolvent was removed under the reduced pressure
4. customdried in vacuum