反应详情

1-{[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]methyl}-3-azetidinecarboxylic acid (50 mg, 0.106 mmol) was added to a mixture of THF (1 mL), water (0.6 mL) and ACN (2 mL), a suspension was obtained to which was added p-TsOH.H2O (24.26 mg, 0.117 mmol). A solution was obtained and stirred for 30 min at rt. Solvent was removed under the reduced pressure and dried in vacuum to give 3-carboxy-1-(3-(5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-2-ethylbenzyl)azetidin-1-ium 4-methylbenzenesulfonate (65 mg) as pale yellow oil.

1. customa suspension was obtained to which
2. customA solution was obtained
3. customSolvent was removed under the reduced pressure
4. customdried in vacuum