HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-Phenylimidazolidine-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1,2-Ethanediamine, N1-phenyl- | HCID 74270 | — |
| Reactant | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Phenylimidazolidine-2-thione | HCID 12269108 | 35.3% |
Reaction Steps
1,1′-Thiocarbonyldiimidazole (4.51 g, 25.3 mmol) was added to a solution of N-phenylethylenediamine (3 mL, 23.02 mmol) in THF (230 mL) and the mixture was stirred for 2 h at room temperature. DCM was added and the solution was washed with 1N HCl, dried over anhydrous sodium sulfate and concentrated under reduced pressure affording title compound 301 (1.45 g, 8.13 mmol, 35.3% yield). m/z: 179.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389541B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b383ff0d62bf4bf0992c4ecd6d0fdd00 |
| Source note | uspto-grants-2013_03 |