4-Chloro-N-methylbenzenamine → HCID 45275192, compound

HRID 1942875Notes

Reaction equation

HRID 1942875 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]3)=[C:13]([O:23][CH3:24])[CH:12]=2)[N:3]=1.[Cl:25][C:26]1[CH:33]=[CH:32][C:29]([NH:30][CH3:31])=[CH:28][CH:27]=1>>[Cl:25][C:26]1[CH:33]=[CH:32][C:29]([N:30]([CH3:31])[C:2]2[N:3]=[C:4]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]4)=[C:13]([O:23][CH3:24])[CH:12]=3)[N:5]=[C:6]([O:8][CH3:9])[N:7]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 702724-Chloro-N-methylbenzenamineHCID 86640783(4-Chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Product 1

HCID 45275192HCID 45275192, compoundYield 14%

Procedure

This compound was prepared from (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and 4-chloro-N-methylaniline in analogy to example 1c. It was purified by column chromatography on Si—NH2 gel (Isolute) using ethyl acetate as eluent to give the title compound as a colorless solid in 14% yield.

Workup

  1. customIt was purified by column chromatography on Si—NH2 gel (Isolute)

Sources & evidence

ORD record
ord-0144cad6d6ce4e94b097db91022a7576
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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