Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-Dichloro-6-(dimethylamino)-1,3,5-triazine | HCID 16985 | — |
| Reactant | (4-Chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine | HCID 86640783 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86668390 | HCID 86668390 | 57% |
Reaction Steps
(4-Chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine (800 mg, 3.94 mmol) was dissolved in 10 ml of methanol and cooled in an ice-bath. Triethylamine (0.6 ml, 4.33 mmol) was added, followed by (4,6-dichloro-[1,3,5]triazin-2-yl)-dimethyl-amine (760 mg, 3.94 mmol; Chem. Pharm. Bull. 45, 291 (1997)). The resulting slurry was stirred for 1 hour at 0° C. and filtered, to give the title compound as a slightly brownish solid in 57% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08389717B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-dbf7ebcc748e4159a39164fb9598884f |
|---|
| Source note | uspto-grants-2013_03 |
|---|
